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Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1

doi:10.1152/ajpregu.00519.2009 280

MedicalDaily Evidence Check Study type: Phase 3 randomized controlled trial (ATTAIN program) Participants: Adults with obesity or overweight with at least one weight-related comorbidity Approval date: April 1, 2026 What it found: Average weight loss of approximately 12.4% (about 27 lbs) at highest dose over 72 weeks What it did not prove: That it matches injectable GLP-1 efficacy

Eur J Heart Fail 23(11):18581871

Cost and access matter, too

Eligibility is determined through clinical screening, and not all applicants will qualify