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Limited long-term research on DSIP has revealed that the full spectrum of side effects may not be completely understood
NRF2 orchestrates the upregulation of several antioxidant genes reliant on GSH, including GSR, solute carrier family 7 member 11 (SLC7A11), glutamatecysteine ligase catalytic subunit (GCLC), and glutamatecysteine ligase modifier subunit, as well as metabolic detoxification genes such as aldehyde dehydrogenase 1 family member A1 and aldoketo reductase family 1 member C1 in cancer cells [66]
This lags behind AST/ALT elevation
Stevens-Johnson syndrome associated with furosemide: a case report
Kurkowska-Jastrzebska I, Babiuch M, Joniec I, Przybykowski A, Czonkowski A (2002) Indomethacin protects against neurodegeneration caused by MPTP intoxication in mice
The majority of human data comes from pharmacological challenge studies rather than therapeutic trials
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