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Chronic uninterrupted use beyond 4 weeks lacks safety data

PI3K, Phosphoinositide 3-Kinase

Arthritis Rheum (2011) 63(6):150716

Although their activity on a single target may be lower compared to single-target drugs, the synergistic effects of multi-target modulation result in a total effect greater than the sum of the individual effects, leading to better efficacy and fewer adverse reactions

Kemp BE, et al

Catalytic-enhanced lactoferrin-functionalized Au-Bi(2) Se(3) nanodots for Parkinsons Disease Therapy via reactive oxygen attenuation and mitochondrial protection