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In contrast, a sedentary lifestyle is associated with increased levels of oxidative stress

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Short-term use (1-2 weeks) may be sufficient for some, while others may require longer periods (4-6 weeks or more) to achieve their goals

Journal of the American Academy of Dermatology, 85 (4), 818829

Contraindications include active thyroid cancer requiring ongoing hormone suppression, history of medullary thyroid carcinoma or MEN2 syndrome, and uncontrolled hypothyroidism