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This is an important discovery that identified the long-sought-after incretin (an intestine-secreted hormone that triggers insulin release) and led to its application as an anti-diabetic strategy

This variant also exacerbates lipid accumulation by disrupting proteasomal degradation of PNPLA3 43

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Weight loss during the first month is often modest - some patients report 2-5 pounds, others report minimal changes

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