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Dihexa was administered orally via gavage at doses of 1.25 mg/kg or 2.0 mg/kg, 25 minutes before behavioral testing

Tracing experiments with Dil-labeled HBs and human ALB (hALB) confirmed that the HBs successfully homed to the injured liver and differentiated into mature hepatocytes

In young rats with scopolamine-induced deficits, all tested Dihexa treatment groups significantly improved water maze performance

PMCID: PMC3533412

These behavioral benefits are underpinned by its marked ability to induce spinogenesis and promote functional synaptogenesis in hippocampal neurons, highlighting its potential as a robust procognitive and antidementia agent [2]

Group 6 received local MSC and Dihexa via Hydrogel and an intravenous injection of MSC