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It has been demonstrated that after 3 years of treatment, approximately 50 % of diabetic patients could achieve acceptable glucose levels with monotherapy

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Moreover, the elevated levels of BAX in SEC-treated groups may play a pivotal role in tumor cell apoptosis induction

Regul Pept (2010) 163(1-3):96101

4.5.3.2 Principal factors influencing biomarker application Impact of renal functional status : when glomerular filtration rate declines, multiple metabolic intermediates accumulate systemically, including branched-chain amino acids and aromatic amino acid catabolites, rendering differentiation between authentic pathogenic markers and consequences of diminished renal clearance capacity difficult (50, 51)