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Source: Jastreboff et al., NEJM 2023 TRIUMPH-4 Phase 3 (68 weeks, 445 participants) Phase 2 Type 2 Diabetes Trial (36 weeks, 281 participants) In the type 2 diabetes population, weight loss was lower than in the obesity trial which is consistent with the pattern seen across all GLP-1 drugs

Mazdutide is a dual agonist activating GLP-1 and glucagon receptors

Anxiety on tirzepatide and muscle pain with tirzepatide have also been reported, though these are less common

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Consult your doctor if there is no weight loss after 16-20 weeks

How long does tirzepatide take to start working