Similarly, PAT-1251 would inhibit both LOXL2 and LOXL3 at 10 M (IC 50 (LOXL2) = 0.87 M, IC 50 (LOXL3) = 1.38 M), but inhibit less than 10% inhibition of diamine oxidases (hDAO) and monoamine oxidase (hMAO) 41
If the vial sat at room temperature for extended periods or was exposed to light, potency decreases and dissolution becomes difficult
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