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No large randomized trial has directly tested this modification against the standard schedule, but retrospective data from obesity medicine practices suggest extended titration reduces early dropout by roughly 20 to 30%

Manoharan S, Madan R

The most common adverse effects associated with GLP-1 medications are gastrointestinal in nature, including nausea, vomiting, diarrhea, constipation, and abdominal discomfort

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