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Actin binding plays a role in cellular movement and tissue repair
The patients at highest risk were those on higher doses, those with pre-existing borderline B12 levels, those with a history of metformin use (which independently depletes B12), and those over age 60
It is not entirely clear if the bacteria penetrate the cells themselves or translocate through the paracellular spaces in these in vitro cultured cell monolayers [76]
The mechanistic complementarity is what makes the stack attractive
Side effect profiles by dose level Every escalation step brings more efficacy and more side effects
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