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Preclinical models using GLP-1estrogen conjugates have shown superior outcomes in metabolic regulation, neuronal viability, and hypothalamic signaling, with reduced systemic estrogenic effects

ALDOC is upregulated in brain cancers, pertinent to the native tissue distribution where ALDOC dominates in the central nervous system 118

These findings underscore the importance of developmental context when evaluating the safety and efficacy of GLP-1 receptor agonists in pediatric populations

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