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The expression of HO-1, a cytoprotective enzyme critical for heme protein metabolism and ferroptosis, was also highly expressed in iron-accumulating renal cells and in mice with hypertensive nephropathy [257, 260, 261]

That makes it a useful reference compound in this area of study

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doi: 10.3390/metabo12040348 8 AngTBruceCRKowalskiGM

20 In 1953, Leroy Stevens discovered that spontaneous testicular teratomas occurred in approximately 1% of the 129-strain male mice they studied, with no significant age-related variation in frequency