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J Biol Chem 283:20212030

A higher level of oxidative stress as evidenced by elevated plasma malondialdehyde levels and low levels of GSH, -tocotrienol and GSH peroxidase activity in patients under 45 years old may play a role in the development of premature coronary artery disease and be potential biomarkers for premature coronary artery disease (153)

SOD1 and SOD3 contain copper and zinc, while SOD2 has manganese in its reactive center

Puerta CDL, Carrascosa-Salmoral MP, Garca-Luna PP, Lardone PJ, Herrera JL, Fernndez-Montesinos R, Guerrero JM, Pozo D

doi: 10.1038/nm.2123, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 131.Corsi L, Momo Dongmo B, Avallone R

Furthermore, clinical studies are also encouraging a randomized, double-blind, controlled trial conducted with 75 bipolar disorder patients for 24 weeks