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Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist, which means it mimics a naturally occurring hormone that helps regulate both blood sugar and appetite

Pancreatic proglucagon gene expression is promoted upon fasting and hypoglycaemia induction and inhibited by insulin

Tirzepatide is unique as a dual GIP and GLP-1 receptor agonist

Hyperamylasaemia and/or hyperlipasaemia: incidence and underlying causes in hospitalized patients with non-pancreatic diseases

Mechanism of Action Glucose Homeostasis: Enhances insulin secretion, suppresses glucagon release Gastric Motility: Delays emptying, promotes satiety signals Cardiovascular: Improves endothelial function, reduces inflammation Neuroprotection: Activates survival pathways, reduces neuroinflammation Renal Protection: Reduces albuminuria, preserves kidney function Hepatic: Improves steatosis, reduces liver inflammation Research Advantages Extended Half-Life: Hours vs