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Wei, G., Darwish, G., Oppenheim, F.G., Schuppan, D., & Helmerhorst, E.J

Dashed arrows indicate negative feedback from circulating T 3 and T 4 to both the hypothalamus and pituitary gland, reducing TRH and TSH secretion

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This combined approach focuses on doing less medication, more effectively

Together, these advances signal a paradigm shift toward personalized , intelligent , and sustainable wound therapeutics