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TB500 is not approved for human use.

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In both monotherapy studies, patients currently on an antihyperglycemic agent discontinued the agent, and underwent a diet, exercise, and drug washout period of about 7 weeks

This does not mean the medication is a failure

145, pp

However, a critical gap across these studies is the general lack of investigation into whether and how these autophagy-modulating agents affect ferroptosis, which limits the assessment of their full relevance to the core crosstalk theme