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Despite promising preclinical data, targeting lipid peroxidation in clinical trials has not been successful [90], indicating that additional research exploring BBB penetrance of potential therapeutics and a better understanding of how lipid peroxides work in the temporal/biological context of TBI will be necessary before these metabolites can be harnessed for clinical benefit

10.1016/j.lfs.2003.07.037 Life Sci

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Smith KR, Granberry M, Tan MCB, Daniel CL, Gassman NR