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Recently, researchers have found that excessive mast cell degranulation in the joints is the cause of osteoarthritis.[ref] To prove this, researchers looked at both human joints and genetic models using mice

PMID: 45 AguirreVUchidaTYenushLDavisRWhiteMF

Somasundaram S, Edmund NA, Moore DT, et al

Oncogenic drivers such as KRAS, cMyc, and HIF1 increase how much glutamine gets taken up and broken down

The single mutants GSAAT(C168S), GSAAT(C190S) and the double mutant GSAAT(C168S/C190S) all showed decreased redox-induced dimerization, suggesting a potential formation of an intramolcular disulfide bridge

Beyond taxonomic shifts, these microbial changes lead to functional alterations in microbial metabolic activity, resulting in modified production of bioactive metabolites that can influence multiple host physiological systems, including the gutovary axis (73, 74)