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As for why Novo would allow its patents to expire, a spokesperson told CNBC that all intellectual property decisions are "carefully considered," and that "periods of exclusivity for pharmaceutical products end as part of their normal life cycle and generic treatments may become available over time." Novo lost its Canadian patent after its lawyers requested a refund for the 2017 patent maintenance fee because the company wanted more time to see if it wanted to pay the required $185

101,102 ME2 depletion, accompanied by an increased NADP + /NADPH ratio and ROS levels, impacts PI3K/AKT signaling and enhances the sensitivity of erythroleukemia and NSCLC cells to cisplatin

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Ploemen JH, van Ommen B, Bogaards JJ, van Bladeren PJ