Close monitoring of side effects: Be aware of the potential side effects and closely monitor for them
Some studies report melanonychia is commonly found in: About 20 in 100 people from Japan About 1.7 in 100 people from China (50 years or older) About 12 in 100 people from Brazil And nearly all people with Afro-Caribbean heritage can get a line on their nail by the time they're 50 years old
Notably, the treatment appeared capable of inducing new hair growth from follicles that were previously inactive an outcome that suggests regenerative potential beyond existing therapies
Who Benefits From Combination Therapy: Provider Decision Framework Combination therapy may be considered in patients with inadequate weight loss response to semaglutide monotherapy alone, documented treatment tolerance after initial side effects, and no contraindications to either agent
But most peptides sold online are promoted for unproven uses, often combined in "stacks," to heal injuries, build muscle, rejuvenate skin or increase energy
FDA-APPROVED INDICATIONS Type 2 diabetes As an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus Limitations of use: has not been studied in patients with a history of pancreatitis TYPE 2 DIABETES RCT SURPASS-2 trial - Tirzepatide vs Semaglutide in Patients with Type 2 Diabetes, NEJM (2021) [PubMed abstract] The SURPASS-2 trial enrolled 1879 adults with type 2 diabetes who were inadequately controlled with metformin at a dose of at least 1500 mg per day Main inclusion criteria Age 18 years T2DM uncontrolled with metformin at 1500 mg/day A1C of 7 - 10.5% BMI 25 and stable for 3 months Main exclusion criteria Type 1 diabetes GFR 50 ng/L
