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However, naphthyl groups are susceptible to metabolic degradation, often proceeding via a 1,2-naphthalene oxide intermediate 4 , which is transformed into glutathione adducts 5 , hydroxynaphthalene derivatives 6 or trans -1,2-dihydro-1,2-dihydroxy naphthyl products 7

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(2021) reported lower Clostridium group IV in PD as well as no strongly associated taxa with levodopa (L-DOPA) use, although preliminary data suggest Clostridium cluster IV may be linked to short-term motor-symptom response to L-DOPA, which deserves a thorough controlled validation

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