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Sulfonylureas: a new look at old therapy

Larger, longer-term trials are needed, but so far, Glucose Control appears to be a helpful addition for people actively managing type 2 diabetes, though effectiveness varies

NICE recommends regular review of weight loss progress, with consideration of treatment discontinuation if less than 5% body weight loss is achieved after 6 months at maintenance dose

For context, semaglutide and tirzepatide do not produce dysesthesia at clinically significant rates, though a recent paper in PMC examined allodynia and dysesthesia reports across GLP-1 medications more broadly

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Medicare does not cover FDA-approved weight-management drugs for weight alone as of April 2026, and manufacturer savings cards typically exclude Medicare enrollees