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Published protocols also note pregnancy, known hypersensitivity to IGF-1 analogs, and pre-existing insulin resistance or diabetes as conditions requiring exclusion or enhanced monitoring in study design

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In addition to the withanolides that are typical of Ashwagandha, the root contains a large number of other natural substances such as various alkaloids (anaferine, anahygrine, cuscohygrine, nicotine, tropine and withasomnine)

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