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doi: 10.1002/9781119312994.apr0135

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From around age 25, the first signs of aging start to become apparent on the surface of skin

Zimmermann MB, Andersson M

The early clinical symptoms of CKD are not obvious, and the renal function gradually deteriorates in the later stage and eventually develops into uremia, that is, end-stage renal disease (ESRD)

Depression patients exhibit reduced parasympathetic activity and relative sympathetic hyperactivity, and this autonomic imbalance inhibits the generation and propagation of propulsive intestinal contractions ( Interstitial cells of Cajal (ICC) dysfunction represents the cellular basis of gut dysmotility