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The body uses several coordinated mechanisms to make this happen: Relaxation of the gastric fundus leads to increased gastric compliance Inhibition of antral contractility reduces propulsive forces Increased pyloric tone creates greater resistance to outflow [2] Research points to the vagal nerve pathway as the main route for this action

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Preparation and characterization of ascorbic acid loaded solid lipid nanoparticles and investigation of their apoptotic effects

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doi: 10.1016/j.it.2020.11.002 55 De FloraS.BalanskyR.La MaestraS

Moreover, microsomal metabolism studies demonstrated that Dihexa had very low phase I metabolism, with an average intrinsic clearance of 2.72 l/min/mg and a half-life of 509.4 minutes