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Similarly, no significant changes in LINE-1 and Alu methylation among female nurses was observed, although several gene-specific hypomethylation effects to the estrogen receptor gene ESR1 (associated with heightened estrogen sensitivity), to the tumor suppressor genes TP53 and BRCA1 (indicating possible disruption in cell cycle regulation and DNA repair mechanisms) were reported

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Weight loss tends to be gradual and steady, which helps support long-term success

Cortisol rhythms shifted toward normalization in stressed subjects (PMID 3923513)

Vitamin C is a powerful antioxidant that can help protect cells from the damage caused by harmful free radicals

Average weight loss ranges from 7 to 12kg, with some patients achieving reductions exceeding 15kg at higher doses