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References 1 International Diabetes Federation

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The primary actions of GLP-1 include stimulating insulin secretion from pancreatic beta cells in response to elevated blood glucose (importantly, this insulin release is glucose-dependent, reducing hypoglycaemia risk), suppressing glucagon release (which prevents the liver from producing excess glucose), and slowing gastric emptying

The initial phase focuses on helping you tolerate the dose while Semaglutide GLP-1 starts influencing appetite regulation and digestion

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GLP-1based therapies reduce: thirst hunger total fluid intake Dehydration can create: headaches irritability increased heart rate hollow chest anxious sensations 4