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Preclinical and clinical data are available evaluating the effect of GLP-1RAs on neurobiological systems and behaviors characteristic of nicotine use and cessation
These compelling Phase II findings paved the way for Phase III REDEFINE-1/2 trials, where CagriSema achieved up to ~22.7% weight loss in obesity and ~13.7% in T2DM, while maintaining a consistent safety profile (145)
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