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First, when you take a pill, it has to be digested and metabolized through the liver or kidney through what is called the first-pass effect

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One cause of B12 deficiency includes pernicious anemia, a condition that results in a reduction of red blood cells when the intestines cannot absorb enough vitamin B12

Current research extrapolations suggest 1216 week treatment cycles followed by 48 week rest periods, though this is based on precautionary principle rather than evidence of receptor desensitization or tolerance development

250 g (see below)

[1] [2] [3] The physiological role of each compound and the effects of supplementation are described below