This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice
Myers said he works in what he described as the Wild West of healthcare, where new compounds emerge faster than the evidence behind them
For more information about the various forms of thiamin deficiency, see the article on Thiamin
There are a number of reasons related to a persons age, dietary practices, stress levels, exposure to toxins, as well as illnesses, which may lower the bodys natural production of glutathione
What sits on the other side of that gap is decades of animal studies showing consistent effects across tissue repair, inflammation, neurological function, and metabolic health
Published laboratory studies have examined 5-Amino-1MQ as an NNMT inhibitor in experimental models