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Proteasome activity is required for anthrax lethal toxin to kill macrophages

Complementary Cellular Protection Each compound protects different cellular compartments and systems: Glutathione excels in cytoplasmic defense and supports the entire cellular antioxidant network Ergothioneine specializes in mitochondrial protection and membrane stabilization PQQ supports energy production pathways while stimulating new mitochondria creation This complementary coverage ensures that cellular energy systems receive protection at multiple levels simultaneously

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Nature 466(7304):388-92 Xie, W., Song, C., Young, NL., Sperling, AS., Xu, F., Sridharan, R., Conway, AE., Garcia, BA., Plath, K., Clark, AT*., Grunstein, M*