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Despite the controversies about the expression of GLP-1R in vascular smooth muscle and endothelial cells, studies have shown that GLP-1RAs have anti-proliferative effects on these cells, and also reduced oxidative stress and increased the production of nitric oxide (NO) (137, 138)

Human studies still needed

Signs of an allergic reaction include severe itching or rash, hives, difficulty breathing or swallowing, lightheadedness, facial flushing, nausea, vomiting, heart palpitations, and swelling of the face, eyes, tongue, or throat

The provider makes an independent clinical judgment about whether GLP-1 medication is appropriate for you

This can be used alongside GLP-1 medications to manage blood sugar levels and weight