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doi: 10.1016/j.supflu.2015.09.012 16

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The higher ceiling dose - 15 mg compared to semaglutide's 2.4 mg - reflects tirzepatide's different pharmacological profile and is part of what drives its greater efficacy in clinical trials

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Its NMR signals are distinct in the ATPS and ADP states and exchange-broadened in the ADPP i state (Fig