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Intestinal epithelial sirtuin 1 regulates intestinal inflammation during aging in mice by altering the intestinal microbiota

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Estimates of effect sizes Most estimates of effect sizes were intermediate to large

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Researchers working with small animal models typically prefer higher concentrations (810mg/ml) to minimize injection volumes below 0.1ml, while protocols requiring frequent dosing over extended periods often use lower concentrations (25mg/ml) to reduce reconstitution frequency and maintain solution stability