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When it is produced by our bodies, which happens in the kidneys, brain and liver, its not metabolised by the gut microbiota and isnt converted to TMAO

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Also, these are effective when the oral supplements you are consuming are not producing any results

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Under physiological conditions, ROS plays a vital role in maintaining cellular homeostasis by regulating the endogenous antioxidant pool ( 2 O 2 production ( Excessive ROS accumulation is an important factor in the pathogenesis of different diseases