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A study on glioblastoma stem cells reported that phenformin, moroxydine, proguanil and cycloguanil exerted a significant impairment of glioblastoma stem cells proliferation, invasiveness and self-renewal ( In vivo , NT1014 reduced tumor weight by 61%, whereas metformin by only 32%

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Importantly, the current evidence supporting this approach is largely indirect and derived from studies conducted in patients with established PsO and metabolic comorbidities, rather than in well-characterized early PsA cohorts.An additional and largely underexplored aspect concerns the safety of combining GLP-1RAs with bDMARDs

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