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The doses studied in clinical trials range from 1mg to 12mg, with 12mg being the highest dose tested and producing the greatest weight loss (-24.2% at 48 weeks in Phase 2, -28.7% at 68 weeks in Phase 3)

Practical Guidelines for Combining Creatine and GLP-1 Dosage & Timing Maintenance: 5 g creatine monohydrate daily

Enhanced Muscle Growth and Retention By increasing IGF-1 and supporting recovery, MK-677 helps maintain and build lean muscle mass, even during periods of reduced training intensity, injury, or cutting

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[4] [14] This widespread receptor distribution explains the hormone's diverse physiological effects beyond glucose regulation