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ORP5/8 facilitate membrane lipid remodeling by directing phosphatidylserine (PS) to mitochondria, where it is converted to phosphatidylethanolamine (PE) at the inner mitochondrial membrane (IMM) through coordinated interactions with OMM proteins such as PTPIP51 or Sam50 [78]
It plays a significant role in protecting the lining of the gastrointestinal tract from damage, promoting healing, and encouraging blood vessel growth
