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Furthermore, the ultra-small copper nanoparticles Cu@CuOx loaded with CCR2-targeting and the chemotherapy drug gemcitabine can inhibit cancer progression and prolong survival by targeting CCR2 to inhibit TAMs recruitment to tumors by targeting CCR2 (28)

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Moreover, not including trial registries and gray literature in order to maintain the robustness and reliability of our manuscript could also emphasize the publication bias in our study