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doi: 10.1038/nri.2016.62 199 WangXYangXLiYWangXZhangYDaiXet al

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It's advisable to discontinue use if these symptoms persist

Instead, move it by one day each week (take it Sunday, then the next week Saturday, then finally Friday) until you reach your goal day

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The Reddit guides say "0.25 mg loading dose." The vial says nothing