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This method is ideal for systemic circulation or when the injury is not localized

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10.1038/sj.bjc.6600610 180 ShirakawaK.TsudaH.HeikeY.KatoK.AsadaR.InomataM.et al (2001)

PEGylation refers to attaching polyethylene glycol molecules to the peptide, improving stability and resistance to degradation in research environments