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The investigators found that starting at a lower dose (2 mg rather than 4 mg) partially blunted the early gastrointestinal side effects the same titrate-slowly principle that governs approved incretin drugs

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For best handling, slowly add the bacteriostatic water down the inside wall of the vial rather than directly onto the powder

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Gastric Emptying Delay: By slowing the rate at which your stomach empties food into the small intestine, GLP-1 extends the window of nutrient absorption and prolongs satiety signals

Tirzepatide is often our first recommendation for patients focused on maximizing results, while semaglutide is a great fit for those who want a gentler start or are working within a tighter budget