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It is important to mention that obesity is a significant risk factor related to several leading causes of death in the United States including: heart disease, cancer, type 2 diabetes, and hypertension, all of which decrease quality of life and life expectancy

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Resmetirom (Rezdiffra TM ), a liver-directed thyroid hormone receptor- (THR-) agonist, received accelerated FDA approval in March 2024 as the first agent specifically indicated for non-cirrhotic MASH with moderate-to-advanced fibrosis (F2-F3), based on the MAESTRO-NASH trial demonstrating MASH resolution and fibrosis improvement