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doi: 10.1161/HYPERTENSIONAHA.120.14868

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You may have found your optimal maintenance dose when: Weight loss is consistent at 0.5-1.0% per week Side effects are manageable and not significantly impacting quality of life Appetite is well controlled without feeling starved Energy levels are stable and adequate for daily activities and exercise Blood glucose and other metabolic markers are improving If these criteria are met at 8mg, there is no clinical obligation to push to 12mg

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However, the patent term on the main compound has been extended by over five years as a result of a Patent Term Adjustment (PTA) and a Patent Term Extension (PTE)

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