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When patients encounter the same allergen again, mast cells and basophils will undergo IgE-mediated activation, which promotes the release of inflammatory mediators, especially histamine and leukotrienes

doi: 10.1186/s12935-022-02624-9 74

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The PGLS gene is located on chromosome 19p13.11 and is composed of 5 exons that encode a 258 amino acid protein

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