Despite its pleiotropic mechanisms, resveratrols clinical translation has been hindered by pharmacokinetic limitations, such as rapid hepatic metabolism, poor aqueous solubility, and low bioavailability, which collectively undermine its therapeutic efficacy [3]
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Bachem, Switzerland) were infused for 1020 min at 3.5 or 12 mmol/l glucose separated by 20 min rest periods to allow secretion to return to basal level
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