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Conjugating E2 to a GLP-1 backbone (GLP1-E2) enables targeted activation of oestrogenic pathways in GLP-1R-expressing beta cells, amplifying local protection while minimising systemic side effects [44]

There is still a major lack of investigation into whether the microenvironment can be mediated and returned to its normal state of homeostasis, with the potential of promoting regeneration and return of function to damaged tissue

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MATLAB R2018a was used to extract the tissue fractions within each voxel