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Blautia, Coprococcus ), while these changes were absent with saxagliptin, consistent with its neutral effect on body weight (29)

Exp Ther Med 17(3):20912098

Unlike traditional weight loss medications that target a single hormonal pathway, tirzepatide's dual-action mechanism stimulates both GLP-1 and GIP receptors

For example, research suggests that weight gain may be particularly detrimental in Asian populations, which is why some advocate for lower BMI ranges for obesity in these ethnic groups (Shai, 2006)

Particularly, the gut pH tremendously affects the concentration of butyrate because of differing tolerance to low pH of the major bacterial functional groups that comprise the human colonic microbiota (60)

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