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3.2.3 Neuroinflammatory imaging in Parkinsons disease Rats overexpressing mutant -synuclein exhibit early, region-specific ([18F]DPA714) binding increases in the substantia nigra and striatum prior to overt dopaminergic neuron loss and motor deficits, indicating that PET-detected microglial activation anticipates classical PD pathology (146)

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These beneficial processes result in reduced tissue damage, upregulated collagen-producing fibroblasts, vessel growth, and cell proliferation

Studies using animal models of obesity have found typical neurobiological characteristics of addiction in the brain systems, which result from behaviors similar to addiction to fat and sugar-rich foods